I spent some time on the Warlock_Destruction_Blue_346 profile. The overall DPS increased from 20070 to 21013 through gear changes and swapping inscription for tailoring. Thanks to the poster above for the tailoring idea. Increased DPS by over 100 compared to inscription.

head=Cowl_of_Pleasant_Gloom,type=cloth,stats=242int_454sta_162hit_182crit_942armor,reforge=crit_haste,gems=ember_shadowspirit_54int_20int_20hit_30int,enchant=60int_35crit
neck=Charm_of_The_Muse,heroic=1,stats=252sta_168int_112hit_112crit,reforge=hit_haste
shoulders=mantle_of_the_eastern_lords,heroic=1,type=cloth,stats=205int_337sta_150mastery_130hit_870armor,reforge=mastery_haste,gems=20int_20haste_10int,enchant=50int_25haste
chest=Robes_of_Orsis,heroic=1,type=cloth,stats=262int_454sta_192hit_172crit_1160armor,reforge=crit_haste,gems=20int_20haste_20int_20hit_20int,enchant=20all
waist=Dreamless_Belt,heroic=0,type=cloth,stats=233int_380sta_149hit_169mastery_704armor,reforge=mastery_haste,gems=20int_20hit_40int_10hit
legs=Breeches_of_Mended_Nightmares,heroic=0,type=cloth,stats=512sta_321int_214crit_216haste_1094armor,reforge=crit_hit,gems=40int_10haste,enchant=95int_80sta
feet=Desert_Walker_Sandals,heroic=1,type=cloth,stats=233int_380sta_169hit_149haste_860armor,gems=40int,enchant=35mastery
wrists=sand_silk_wristband,heroic=1,type=cloth,stats=168int_252sta_112crit_112hit_507armor,reforge=hit_haste,enchant=65haste
hands=Flamebloom_Gloves,heroic=0,type=cloth,stats=233int_380sta_149haste_169mastery_725armor,reforge=mastery_hit,gems=20hit_20int_10int,enchant=50haste
finger1=band_of_rays,heroic=1,stats=168int_252sta_112crit_112hit,reforge=crit_haste,enchant=40int
finger2=lavishly_jeweled_ring,heroic=1,stats=133int_252sta_112mastery_107hit,reforge=mastery_haste,gems=40int_10hit,enchant=40int
trinket1=witching_hourglass,heroic=1,stats=285int,equip=onspellcast_1710haste_10%_15dur_75cd
trinket2=Darkmoon_Card:_Tsunami,heroic=0,stats=321int
back=Shadow_of_Perfect_Bliss,heroic=1,stats=168int_252sta_85hit_128crit_580armor,reforge=crit_haste,enchant=lightweave_embroidery_2
main_hand=modguds_blade,heroic=1,stats=129int_194sta_86crit_86hit_1729sp,reforge=crit_haste,enchant=power_torrent,weapon=dagger_1.80speed_516min_958max
off_hand=beautys_favorite_bone,heroic=1,stats=168int_252sta_98crit_120hit,reforge=crit_haste,enchant=100int
ranged=corlas_baton,heroic=1,stats=95int_143sta_68mastery_56hit,reforge=mastery_haste
# Gear Summary
# gear_strength=20
# gear_agility=20
# gear_stamina=4846
# gear_intellect=4355
# gear_spirit=20
# gear_spell_power=1729
# gear_hit_rating=1756
# gear_crit_rating=858
# gear_haste_rating=1298
# gear_mastery_rating=438
# gear_armor=7442
# meta_gem=ember_shadowspirit
# main_hand=modguds_blade,heroic=1,weapon=dagger_1.80speed_516min_958max,enchant=power_torrent

Still working on some tweaks, but running out if ideas.

*Edit. Meta not activated in first post. Now fixed.

*2nd Edit: Switched Enchant on hands, switched Trinket2 to Darkmoon Card: Tsunami