@Kyruski: The blood strike specific portion of your testing will need to be redone next PTR patch, as the bonus damage from diseases is being cut in half (50%->25%). Also, I believe the better test is whether 2x BS > 2x IT + FS, as that's currently the ideal way to spend those death runes as frost. I guess with the FS nerfs the value of 2x IT + FS might need to be re-evaluated compared to Ob, however. And I can confirm that CG (all proc-based rune enchants, actually) do proc from strikes. The easiest way to test this is to gradually face away from the dummy until you can no longer hit it with auto attacks. If you do it incrementally enough, you should still be able to use special attacks. Spam them for a few seconds until you get a proc, and voila.

Blood strike - Is it now doing enough damage to justify using Death runes for BS instead of other attacks?

Unfortunately I don't think this question has a simple yes/no answer. It's actually a bit of a chicken and egg problem, in that we only care about the answer for the highest DPS DW build, but we're not sure yet which that is. I'll take a stab at this for deep frost, but 23/48 and deep unholy would need a separate set of calculations.

**Assumptions**- BS damage is increased by 25% per disease, using the latest patch notes.
- Not factoring in any sigils, since SotVH likely won't be BiS next patch
- Using glyphs of IT and FS
- For ease of calculation, assume paired weapons of the same speed and DPS. This lets us calculate total BS/FS damage by multiplying the MH damage by 1.575
- Assume raid buffs and spell hit cap. BS/FS are mostly affected by the same buffs - BS will gain 4% damage relative to FS (Blood Frenzy), and IT will gain 13% damage.
- I'm ignoring crit chance for now, because it's pretty complicated, especially with KM procs. But see below on why I don't think that affects the outcome.
- Given the glyph choices, the comparison is really 2x BS vs. 2x IT + 93.75% of a FS

Weapon damage = wpn_base + AP / 14 * 2.4

BS damage = (0.4 * wpn + 305.6) * 1.5 * 1.1 * 1.575 * 1.04

FS damage = (0.55 * wpn + 138) * 1.1 * 1.1 * 1.15 * 1.2 * 1.575 * .9375

IT damage = (236 + AP * .1) * 1.1 * 1.15 * 1.15 * 1.2 * 1.13

Feel free to plug in various AP and weapon damage numbers. There is no one answer, even given the assumptions listed, because the BS option scales worse with AP but better with weapon damage. However, what I consider to be all sane values ITx2 wins handily. Now, I didn't consider crit. Ignoring Dark Conviction, IT has 15% crit from talents, FS has 3%, and BS has 12%. If we generously assume that 1% crit = 1% increased damage (it's less, but bear with me)

**and** we ignore the crit that IT and FS get, then with 5500 AP and two 2.6s ilvl 239 weapons, 2x BS is better than 2x IT + FS. Except we haven't considered armor. BS is affected by it, 2x IT + FS isn't. Again, this is somewhat subjective because everyone will have a different idea of what a reasonable amount of ArP is, but if we assume the boss has even 10% damage reduction from armor, then 2x IT + FS pulls ahead again by a decent margin.

**Conclusions**I think that calculating the exact average damage of each option will require a full-fledged spreadsheet, or ideally, an updated simulator. However, I feel that the scenario above is proof that for the average case, ITx2 is a better use of death runes

*for a 51 frost spec that is glyphed for IT and FS*, since it outperforms 2x BS in a situation that is very favorable for 2x BS (only 10% reduction from armor, and ignoring IT/FS damage increases from crit). This raises several new questions though, like whether the current deep frost glyphs will still be the best choices in 3.2, and how deep frost stacks up to 23/48 overall. So while I don't have time to calculate the answer to this question for the various other specs, hopefully this will prove useful in getting the ball rolling.